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| 品牌 | absin | CAS | 126-17-0 |
|---|---|---|---|
| 分子式 | C27H43NO2 | 純度 | ＞98% |
| 分子量 | 413.6 | 貨號 | abs42156447 |
| 規格 | 100mg | 供貨周期 | 現貨 |
| 主要用途 | is a poisonous alkaloid chemical compoun | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Solasodine 126-17-0
| 產品描述 | |
| 描述 | Solasodine(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and human myeloid leukemia cell line (U937). |
| 純度 | 98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | Purapuridine；Solancarpidine；Solasodin |
| 外觀 | white to beige powder |
| 可溶性/溶解性 | DMSO : 2.6 mg/mL (6.29 mM; Need ultrasonic) |
| 生物活性 | |
| In vitro(體外研究) | Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated into cholinergic neurons that expressed specific neuronal markers and displayed important axonal formation that continued growing even 30 days after treatment . |
| In vivo(體內研究) | A 2-week infusion ofsolasodine into the left ventricle of the rat brain followed by a 3-week washout resulted in a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining, demonstrating the proliferative and differentiating properties of solasodine on neuronal progenitors. Solasodine treatment in rats resulted in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells, suggesting a possible role played by neurosteroid production in solasodine-induced neurogenesis. In GAD65-GFP mice that express the green fluorescent protein under the control of the glutamic acid decarboxylase 65-kDa promoter, solasodine treatment increased the number of GABAergic progenitors and neuroblasts generated in the subventricular zone and present in the olfactory migratory tract. |
| 研究領域 | |
| 研究領域 | CancerCell cycleCell cycle inhibitorsp53 pathway CancerOncoproteins/suppressorsTumor suppressorsp53 pathway ApoptosisIntracellularp53 Pathway Cell CycleCell Cycle Inhibitorsp53 EpigeneticsCell cycleCell Cycle Inhibitorsp53 EpigeneticsDNA / RNADNA Damage & RepairDNA Damage Responsep53 EpigeneticsTranscriptionCancer susceptibilityTumor Suppressors NeuroscienceDevelopment NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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