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| 品牌 | absin | CAS | 59865-13-3 |
|---|---|---|---|
| 分子式 | C62H111N11O12 | 純度 | ＞99% |
| 分子量 | 1202.63 | 貨號 | abs810016 |
| 規格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | 是一種免疫抑制劑 | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
Cyclosporin A 59865-13-3
| 產品描述 | |
| 描述 | CyclosporinA是一種免疫抑制劑，與親環素結合，隨后抑制calcineurin，無細胞試驗中IC50為7nM，廣泛用于預防器guan移植反應中的排斥反應。 在T細胞中，CyclosporinA與親環蛋白(免疫親和素)結合，形成親環蛋白-CyclosporinA復合體，其結合并抑制鈣調磷酸酶。CyclosporinA抑制鈣調磷酸酶，IC50是7nM，隨后阻斷NF-AT核轉運。CyclosporinA通過抑制MTP(線粒體通透性轉換孔)的開放而影響線粒體，IC50是39nM。 |
| 純度 | >99 % |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | huan孢素A;Cyclosporine A |
| 外觀 | white solid |
| 可溶性/溶解性 | DMSO：100 mg/mL warmed (83.15 mM) Ethanol：100 mg/mL warmed (83.15 mM) |
| 生物活性 | |
| 靶點 | calcineurin |
| In vitro(體外研究) | Cyclosporin A binds to the cyclophilin (immunophilin) in T cells , forms a Cyclophilin-Cyclosporin A complex which the binds to and inhibits calcineurin. Cyclosporin A inhibits calcineurin with IC50 of 7 nM, then blocks the nuclear translocation of NF-AT. Cyclosporin A also affects mitochondria by preventing the MTP (mitochondrial permeability transition pore) from opening with an IC50 of 39 nM. |
| In vivo(體內研究) | Cyclosporin A is an immunosuppressive agent that is effective following either parenteral or oral administration in mice, rat and guinea pigs. , is clinically used in organ transplantation to prevent rejection. |
| 研究領域 | |
| 研究領域 | CardiovascularBloodOther ImmunologyImmune InterventionsTransplantation Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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