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| 品牌 | absin | CAS | 209984-57-6 |
|---|---|---|---|
| 分子式 | C26H23F2N3O4 | 純度 | ＞98% |
| 分子量 | 479.48 | 貨號 | abs810748 |
| 規格 | 5mg | 供貨周期 | 現貨 |
| 主要用途 | is a potent γ-secretase inhibitor with I | 應用領域 | 化工,生物產業,農林牧漁,制藥/生物制藥,綜合 |
LY-411575 209984-57-6
| 產品描述 | |
| 描述 | LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM. |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | LY411575；LY 411575 |
| 外觀 | white to beige Powder |
| 可溶性/溶解性 | DMSO : 33.33 mg/mL (69.51 mM; Need ultrasonic) |
| 生物活性 | |
| 靶點 | γ secretase (membrane-based)；γ secretase (cell-based) ；Notch S3 cleavage |
| In vitro(體外研究) | LY-411575 inhibits γ-secretase which can be assessed by the substrates like amyloid precursor protein (APP) and Notch S3 cleavage. LY-411575, which blocks Notch activation, results in apoptosis in primary and immortalized KS cells. |
| In vivo(體內研究) | 10 mg/kg oral dose of LY-411575 decreases brain and plasma Aβ40 and -42 dose-dependently. LY-411575 reduces cortical Aβ40 in young (preplaque) transgenic CRND8 mice (ED50 ≈ 0.6 mg/kg) and produces significant thymus atrophy and intestinal goblet cell hyperplasia at higher doses (>3 mg/kg). The therapeutic window is similar after oral and subcutaneous administration and in young and aged CRND8 mice. Both the thymus and intestinal side effects are reversible after a 2-week washout period. Three-week treatment with 1 mg/kg LY411575 reduces cortical Aβ40 by 69% without inducing intestinal effects, although a previously unreported change in coat color is observed. |
| 研究領域 | |
| 研究領域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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