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簡要描述：IM-12 1129669-05-1The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.
產(chǎn)品型號：abs810638廠商性質(zhì)：生產(chǎn)廠家更新時間：2026-02-24訪 問 量：2174產(chǎn)品分類
Product Category詳細(xì)介紹
| 品牌 | absin | CAS | 1129669-05-1 |
|---|---|---|---|
| 分子式 | C22H20FN3O2 | 純度 | ＞98% |
| 分子量 | 377.41 | 貨號 | abs810638 |
| 規(guī)格 | 5mg | 供貨周期 | 現(xiàn)貨 |
| 主要用途 | IM-12 is a selective GSK-3β inhibitor w | 應(yīng)用領(lǐng)域 | 化工,生物產(chǎn)業(yè),農(nóng)林牧漁,制藥/生物制藥,綜合 |
IM-12 1129669-05-1
| 產(chǎn)品描述 | |
| 描述 | The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling. |
| 純度 | >98% |
| 儲存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 別名 | The GSK3β Inhibitor XIX, IM 12, IM-12,IM12 |
| 外觀 | Powder |
| 可溶性/溶解性 | Ethanol ：10 mg/mL (26.49 mM) warmed DMSO ：70 mg/mL (185.5 mM) |
| 生物活性 | |
| 靶點 | GSK-3β |
| In vitro(體外研究) | In hNPCs, IM-12 inhibits GSK-3β activity with IC50 of 3.8 μM and subsequently increases β-catenin concentration significantly. Through the activation of canonical Wnt signalling pathway, IM-12 promotes the neuronal differentiation of human neural progenitor cells. |
| 研究領(lǐng)域 | |
| 研究領(lǐng)域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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